ISSN 2394-5125
 

Review Article 
JCR. 2016; 3(4): 11-16


INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ.

Abstract
Solid lipid nanoparticles (SLNp) are a new class of alternative colloidal carriers developed at the beginning of the 1990s with the particle size ranging from 50 to 1000 nm. The SLNp consists of the drug molecule, surfactants, and solid lipid core suitable for incorporation of lipophilic, hydrophilic, and poorly water-soluble molecules. Diabetes mellitus (DM), is a prototype multifactorial complex diseases that regarded as one as one of the leading causes of morbidity and mortality in the world. DM caused by inadequate secretion of insulin or by the damaged cells of Islet of Langerhans of the pancreas. The present review provides information about the suitable choice of lipid, amount of surfactants was used for SLNp preparation, characterization, and various route of administration to increase the relative oral bioavailability in diabetic animals. Moreover, limitations associated with nanocarrier system for insulin delivery have also been discussed. Solid lipid Nanoparticulate system might be efficiently overcome peripheral hyper insulinemia, lipo-hyper-atrophy and improves the life quality of diabetic patients in the near future.

Key words: Diabetes mellitus, Palmitic acid, Nanocarrier system, Microscopy


 
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Pubmed Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ. INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS. JCR. 2016; 3(4): 11-16.


Web Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ. INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS. http://www.jcreview.com/?mno=302644784 [Access: June 02, 2021].


AMA (American Medical Association) Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ. INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS. JCR. 2016; 3(4): 11-16.



Vancouver/ICMJE Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ. INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS. JCR. (2016), [cited June 02, 2021]; 3(4): 11-16.



Harvard Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ (2016) INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS. JCR, 3 (4), 11-16.



Turabian Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ. 2016. INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS. Journal of Critical Reviews, 3 (4), 11-16.



Chicago Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ. "INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS." Journal of Critical Reviews 3 (2016), 11-16.



MLA (The Modern Language Association) Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ. "INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS." Journal of Critical Reviews 3.4 (2016), 11-16. Print.



APA (American Psychological Association) Style

SATYAVANI KALIAMURTHI, GURUDEEBAN SELVARAJ (2016) INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS. Journal of Critical Reviews, 3 (4), 11-16.