ISSN 2394-5125
 

Review Article 
JCR. 2016; 3(2): 11-16


ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION

VAIBHAV WALIA.

Abstract
Depression is one of the most prevalent neuropsychiatric disorders that occurs due to the alterations in the monoaminergic system of the body. Various factors may be responsible for the alterations in the monoaminergic system. MAO-A is an enzyme which metabolizes the monoamines and thus responsible for the reduction in the level of monoamines in the body. Stress induces the increase expression and levels of various proinflammatory cytokines such as IL-6, IL-1β, TNF-α and PGE2 involved in the pathogenesis of depression. These proinflammatory cytokines increase or decrease the activity of various enzymes that further led to the reduction in the serotonin level of the brain. Thus, it has been suggested that the depression which is considered as a disorder that arises due to the imbalance in the neurotransmitters in the brain arises due to the alterations in the activities of the various enzymes. Therefore the aim of present review is to demonstrate the role of the various enzymes in the pathogenesis of depression.

Key words: Depression, Enzymes, Nitric oxide, Stress.


 
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Pubmed Style

VAIBHAV WALIA. ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION. JCR. 2016; 3(2): 11-16.


Web Style

VAIBHAV WALIA. ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION. http://www.jcreview.com/?mno=302644762 [Access: May 30, 2021].


AMA (American Medical Association) Style

VAIBHAV WALIA. ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION. JCR. 2016; 3(2): 11-16.



Vancouver/ICMJE Style

VAIBHAV WALIA. ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION. JCR. (2016), [cited May 30, 2021]; 3(2): 11-16.



Harvard Style

VAIBHAV WALIA (2016) ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION. JCR, 3 (2), 11-16.



Turabian Style

VAIBHAV WALIA. 2016. ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION. Journal of Critical Reviews, 3 (2), 11-16.



Chicago Style

VAIBHAV WALIA. "ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION." Journal of Critical Reviews 3 (2016), 11-16.



MLA (The Modern Language Association) Style

VAIBHAV WALIA. "ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION." Journal of Critical Reviews 3.2 (2016), 11-16. Print.



APA (American Psychological Association) Style

VAIBHAV WALIA (2016) ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION. Journal of Critical Reviews, 3 (2), 11-16.