ISSN 2394-5125
 

Review Article 


SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT

RUBENDRA KURMI1, DINESH KUMAR MISHRA, DINESH KUMAR JAIN.

Abstract
Poor solubility of drugs is a major challenge in the formulation development. Solid dispersion is introduced as a novel means for enhancement of solubility. Solid dispersion may be defined as a set of solid products comprising of at least two diverse components, usually hydrophilic matrix and hydrophobic drug. This matrix may be crystalline or amorphous in nature. As per biopharmaceutical classification system class II drugs are with low solubility and high permeability and are the promising candidates for improvement of solubility as well as bioavailability by means of solid dispersion. Practical aspects pertaining to preparation of solid dispersions, like the selection of carrier, drugs molecular arrangement in these preparations are discussed in this article. Proposed article highlights the various preparation techniques of solid dispersion, characterization, available recent technologies, marketed preparation, future prospective etc.

Key words: Matrix, Solubility, Carrier, Solid dispersion.


 
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How to Cite this Article
Pubmed Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN. SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT. JCR. 2016; 3(1): 1-8.


Web Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN. SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT. http://www.jcreview.com/?mno=302644757 [Access: April 10, 2021].


AMA (American Medical Association) Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN. SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT. JCR. 2016; 3(1): 1-8.



Vancouver/ICMJE Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN. SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT. JCR. (2016), [cited April 10, 2021]; 3(1): 1-8.



Harvard Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN (2016) SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT. JCR, 3 (1), 1-8.



Turabian Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN. 2016. SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT. Journal of Critical Reviews, 3 (1), 1-8.



Chicago Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN. "SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT." Journal of Critical Reviews 3 (2016), 1-8.



MLA (The Modern Language Association) Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN. "SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT." Journal of Critical Reviews 3.1 (2016), 1-8. Print.



APA (American Psychological Association) Style

RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN (2016) SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT. Journal of Critical Reviews, 3 (1), 1-8.