ISSN 2394-5125
 

Research Article 


Pharmacogenomics and Pharmacogenetics of Anticancer Agents

Aakifa Ahmad, Gunjan, Pankaj Taneja.

Abstract
Cancer Chemotherapy is marked by a wide spectrum of effectiveness and toxicity of medication. In Pharmacokinetics, the vast majority of anti-cancer drugs has huge inter-individual variability and has minor therapeutic windows. As the inter-individual variance in pharmacokinetics is often crucial to the processing of medications, pharmacogenomic analyses of medication metabolizing enzymes can rationalize treatment, patient and selection of dosage. In response and toxicity related to anticancer therapy, a large inter-individual variation is observed. Such variability is etiologically widespread, which is attributed partly to genetic differences in the host. Pharmacogenetic and pH studies also successfully established hereditary variations due to this variation in susceptibility to chemotherapy.This research addresses the following: evaluating the effect of genetics on drug response; recognizing, validating genetic markers and reviewing genetically engineered markers; therapeutic effects and clinical value assessments. With technological advancement, a relatively cost-effective and efficient assessment of the human genome is possible, but comprehensive clinical work and training remain essential to enhance the transfer of pharmacogenetic principles from bench to bedside.

Key words: Anticancer Drug, Candidate Gene Approach, Drug-Metabolizing Enzymes, Genome Wide Approach, Irinotecan, Pharmacogenomics


 
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How to Cite this Article
Pubmed Style

Aakifa Ahmad, Gunjan, Pankaj Taneja. Pharmacogenomics and Pharmacogenetics of Anticancer Agents. JCR. 2020; 7(10): 1128-1132. doi:10.31838/jcr.07.10.221


Web Style

Aakifa Ahmad, Gunjan, Pankaj Taneja. Pharmacogenomics and Pharmacogenetics of Anticancer Agents. http://www.jcreview.com/?mno=120808 [Access: August 18, 2021]. doi:10.31838/jcr.07.10.221


AMA (American Medical Association) Style

Aakifa Ahmad, Gunjan, Pankaj Taneja. Pharmacogenomics and Pharmacogenetics of Anticancer Agents. JCR. 2020; 7(10): 1128-1132. doi:10.31838/jcr.07.10.221



Vancouver/ICMJE Style

Aakifa Ahmad, Gunjan, Pankaj Taneja. Pharmacogenomics and Pharmacogenetics of Anticancer Agents. JCR. (2020), [cited August 18, 2021]; 7(10): 1128-1132. doi:10.31838/jcr.07.10.221



Harvard Style

Aakifa Ahmad, Gunjan, Pankaj Taneja (2020) Pharmacogenomics and Pharmacogenetics of Anticancer Agents. JCR, 7 (10), 1128-1132. doi:10.31838/jcr.07.10.221



Turabian Style

Aakifa Ahmad, Gunjan, Pankaj Taneja. 2020. Pharmacogenomics and Pharmacogenetics of Anticancer Agents. Journal of Critical Reviews, 7 (10), 1128-1132. doi:10.31838/jcr.07.10.221



Chicago Style

Aakifa Ahmad, Gunjan, Pankaj Taneja. "Pharmacogenomics and Pharmacogenetics of Anticancer Agents." Journal of Critical Reviews 7 (2020), 1128-1132. doi:10.31838/jcr.07.10.221



MLA (The Modern Language Association) Style

Aakifa Ahmad, Gunjan, Pankaj Taneja. "Pharmacogenomics and Pharmacogenetics of Anticancer Agents." Journal of Critical Reviews 7.10 (2020), 1128-1132. Print. doi:10.31838/jcr.07.10.221



APA (American Psychological Association) Style

Aakifa Ahmad, Gunjan, Pankaj Taneja (2020) Pharmacogenomics and Pharmacogenetics of Anticancer Agents. Journal of Critical Reviews, 7 (10), 1128-1132. doi:10.31838/jcr.07.10.221