2.8 m/sec. Results: The peak early trans-mitral filling wave velocity (E) was low in subjects with diabetic retinopathy [40 11.6 cm/s vs 46 9.6cm/s]. Mean of E/A ratio in subjects with diabetic retinopathy group was significantly lower compared to those without retinopathy (p < 0.03). The E/e ratio was significantly higher in subjects with retinopathy (15.7 2.48 vs 13.24 1.88, p" />
ISSN 2394-5125
 

Review Article 


RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil.

Abstract
Background: Prevalence of heart failure in asymptomatic type 2 DM subjects is increasing. Presence of microvascular complications like retinopathy and microalbuminuria, is under evaluation for predicting cardiovascular complications like heart failure in type 2 DM subjects. Aims and objectives: To study the relation between diabetic retinopathy and microalbuminuria with presence and grades of diastolic dysfunction in type 2 diabetes mellitus (DM) subjects. Materials and methods: This was a cross-sectional, observational study. A total of 62 subjects with type 2 diabetes mellitus (Type-2 DM) were enrolled. Fundoscopy examination for diabetic retinopathy, urine for microalbuminuria and standardized transthoracic echocardiographic (TTE) examination were performed. Left ventricular diastolic dysfunction (LVDD) was labeled if ≥3 of variables were present: "Septal e <7 cm/sec or Lateral e <10 cm/sec, E/e ratio >14, LA volume index >34 mL/m2, Peak TR velocity >2.8 m/sec. Results: The peak early trans-mitral filling wave velocity (E) was low in subjects with diabetic retinopathy [40 11.6 cm/s vs 46 9.6cm/s]. Mean of E/A ratio in subjects with diabetic retinopathy group was significantly lower compared to those without retinopathy (p < 0.03). The E/e ratio was significantly higher in subjects with retinopathy (15.7 2.48 vs 13.24 1.88, p<0.02). The subjects with retinopathy and/or microalbuminuria had lower mean E/A ratio, deceleration time (DT), e' and higher E/e' ratio. Total 14(22.58%) subjects had diabetic retinopathy, all had mild non-proliferative diabetic retinopathy (NPDR) and 20(32.26%) subjects had microalbuminuria. Total 28 (45.16%) subjects had diastolic dysfunction [grade I: 24 (85.71%), grade-II: 4 (14.29%)]. Amongst 28 subjects with LVDD, 10(35.71%) had diabetic retinopathy and 15(53.57%) had microalbuminuria. Significant association was present between presence of retinopathy and microalbuminuria with diastolic dysfunction (p=0.024 and 0.001, respectively). Conclusion: Prevalence of LVDD in asymptomatic type 2 diabetes mellitus subject was 45.16%. Present study highlighted strong association between presence of diabetic retinopathy and microalbuminuria with LV diastolic dysfunction in subjects with type 2 diabetes mellitus.

Key words: Diabetic retinopathy, microalbuminuria, Left ventricular diastolic dysfunction, LVDD, E/A ratio, E/e ratio


 
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Pubmed Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil. RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS. JCR. 2020; 7(5): 981-986. doi:10.31838/jcr.07.05.199


Web Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil. RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS. http://www.jcreview.com/?mno=101008 [Access: August 18, 2021]. doi:10.31838/jcr.07.05.199


AMA (American Medical Association) Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil. RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS. JCR. 2020; 7(5): 981-986. doi:10.31838/jcr.07.05.199



Vancouver/ICMJE Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil. RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS. JCR. (2020), [cited August 18, 2021]; 7(5): 981-986. doi:10.31838/jcr.07.05.199



Harvard Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil (2020) RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS. JCR, 7 (5), 981-986. doi:10.31838/jcr.07.05.199



Turabian Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil. 2020. RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS. Journal of Critical Reviews, 7 (5), 981-986. doi:10.31838/jcr.07.05.199



Chicago Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil. "RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS." Journal of Critical Reviews 7 (2020), 981-986. doi:10.31838/jcr.07.05.199



MLA (The Modern Language Association) Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil. "RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS." Journal of Critical Reviews 7.5 (2020), 981-986. Print. doi:10.31838/jcr.07.05.199



APA (American Psychological Association) Style

Virendra C. Patil, Akshay R. Kulkarni, Harsha V. Patil (2020) RELATION OF RETINOPATHY AND MICROALBUMINURIA WITH DIASTOLIC DYSFUNCTION IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS. Journal of Critical Reviews, 7 (5), 981-986. doi:10.31838/jcr.07.05.199