ISSN 2394-5125
 

Research Article 


THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev.

Abstract
Background. Postoperative cognitive dysfunction (POCD)has been shown to be associated with long-term disability, higher healthcare costs, and even increased mortality. Etiology of POCD is not clearly understood. The induction of neuroinflammation, following the release of damage-associated patterns appears to play an important role. Objective of study was to assess the influence of minor and major surgery on cognitive functions of rats.
Methods. Study was performed on rats (n=60). They were allocated to minor (n=20) and major (n=20) surgery groups. For minor and major surgery group animals sham laparotomy and laparotomy with nephrectomy was performed respectively under isoflurane anesthesia. Cognitive functions of rats were assessed from postoperative day 7 to day 24 using Morris water maze (MWM) test and object recognition test. Results were compared to control group (n=20).
Results. The learning session of MWM demonstrated learning ability in all group animals, but significant learning deficit was observed in minor and major surgery groups. Short-memory deficit was observed only in time till 1st target area crossing (tTAC, p=0.035), but in major surgery group it was observed in all parameters of MWM, tTAC (p=0.02), target area crossings (TAC, p=0.049) and target quadrant time (TQT, p=0.038). Upon assessing long-term memory in minor group TQT (p=0.004) and TAC (p=0.042) differed significantly in comparison to control animals. In major group animals all test parameters were indicative of long-term memory impairment, tTAC (p=0.013), TQT (p=0.0005) and TAC (p=0.008). Object recognition 8 and 24 days after surgery did not reveal significant difference between minor surgery and control group by discrimination index (p=0.11 and p=0.08). Whereas major surgery group results indicated memory deficit in both time periods (p=0.019 and p=0.005).
Conclusion.Both minor and major surgery may cause cognitive disorders in the postoperative period, but the extent of cognitive function deficits were higher in major surgery group animals.

Key words: postoperative cognitive dysfunction, major surgery, Morris water maze, object recognition test.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by V.Kh. Sharipova
Articles by A.A. Valihanov
Articles by A.H. Alimov
Articles by J.G. Abdullaev
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev. THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS. JCR. 2020; 7(17): 2269-2274. doi:10.31838/jcr.07.17.279


Web Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev. THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS. http://www.jcreview.com/?mno=96008 [Access: August 17, 2021]. doi:10.31838/jcr.07.17.279


AMA (American Medical Association) Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev. THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS. JCR. 2020; 7(17): 2269-2274. doi:10.31838/jcr.07.17.279



Vancouver/ICMJE Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev. THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS. JCR. (2020), [cited August 17, 2021]; 7(17): 2269-2274. doi:10.31838/jcr.07.17.279



Harvard Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev (2020) THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS. JCR, 7 (17), 2269-2274. doi:10.31838/jcr.07.17.279



Turabian Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev. 2020. THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS. Journal of Critical Reviews, 7 (17), 2269-2274. doi:10.31838/jcr.07.17.279



Chicago Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev. "THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS." Journal of Critical Reviews 7 (2020), 2269-2274. doi:10.31838/jcr.07.17.279



MLA (The Modern Language Association) Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev. "THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS." Journal of Critical Reviews 7.17 (2020), 2269-2274. Print. doi:10.31838/jcr.07.17.279



APA (American Psychological Association) Style

V.Kh. Sharipova, A.A. Valihanov, A.H. Alimov, J.G. Abdullaev (2020) THE EFFECTS OF MINOR AND MAJOR SURGERY ON COGNITIVE FUNCTIONS IN RATS. Journal of Critical Reviews, 7 (17), 2269-2274. doi:10.31838/jcr.07.17.279