ISSN 2394-5125
 

Research Article 


BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira.

Abstract
Purpose of the study is toassess the diagnostic and prognostic value of NSE, interleukins (IL-β and TFN-α) in newborns with congenital pneumonia (СР) with central nervous system damage.
Materials and methods. 90 newborns with confirmed congenital pneumonia (CP) were examined. According to the presence of CNS damage, children were divided into 2 groups: group 1 consisted of 58 children with CP lesion of the central nervous system, group 2 - 40 children of CP without a central nervous system lesion. All children underwent determination of the content of cytokines and the level of NSE in the blood serum.
The results of the study. Assessment of the NSE level in the groups on 3-5 days of life showed that the concentration of NSEand cytokines in children of the 1st group was significantly higher compared to newborns of the 2nd group.In the 1st group of children, a reliable relationship was established between the NSE and interleukins in the blood, which indicates a parallel increase in these indicators in case of central nervous system lesions. In newborns of group 1 CP on the 14th day of life, a decrease in the concentration of NSE, TFN-α was noted, while the concentration of NSE andIL-1βin the blood serum of newborns did not reach normal, as in the control group.In children of the 2nd group, there was a decrease in all indicators to normal values, that is, to the values of the control group.

Key words: congenital pneumonia,IL-1β, TFN-α, newborns, neurospecific enolase,central nervous system damage.


 
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How to Cite this Article
Pubmed Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira. BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS. JCR. 2020; 7(17): 2265-2268. doi:10.31838/jcr.07.17.278


Web Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira. BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS. http://www.jcreview.com/?mno=96003 [Access: August 18, 2021]. doi:10.31838/jcr.07.17.278


AMA (American Medical Association) Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira. BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS. JCR. 2020; 7(17): 2265-2268. doi:10.31838/jcr.07.17.278



Vancouver/ICMJE Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira. BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS. JCR. (2020), [cited August 18, 2021]; 7(17): 2265-2268. doi:10.31838/jcr.07.17.278



Harvard Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira (2020) BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS. JCR, 7 (17), 2265-2268. doi:10.31838/jcr.07.17.278



Turabian Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira. 2020. BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS. Journal of Critical Reviews, 7 (17), 2265-2268. doi:10.31838/jcr.07.17.278



Chicago Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira. "BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS." Journal of Critical Reviews 7 (2020), 2265-2268. doi:10.31838/jcr.07.17.278



MLA (The Modern Language Association) Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira. "BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS." Journal of Critical Reviews 7.17 (2020), 2265-2268. Print. doi:10.31838/jcr.07.17.278



APA (American Psychological Association) Style

Abdurakhmanova Fatima, Salikhova Kamola, Ishniyazova Nadira (2020) BIOCHEMICAL AND IMMUNOLOGICAL PECULIARITIES OF THE COURSE OF CONGENITAL PNEUMONIA IN NEWBORNS WITH LESIONS OF CNS. Journal of Critical Reviews, 7 (17), 2265-2268. doi:10.31838/jcr.07.17.278