ISSN 2394-5125
 

Review Article 


HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko.

Abstract
Purpose of the study - to analyze the frequency and severity of hormonal changes in the hypothalamus-pituitary-adrenal-gonads system in young men with hypothalamic syndrome and alimentary-constitutional obesity. Materials and methods. We examined 340 males (mean age 21.272.44 years). Examined patients were divided into the following groups: Group I ‒ hypothalamic syndrome of the late puberty (n=84); Group II ‒ constitutional-exogenous obesity of the late puberty (n=20); Group III ‒ hypothalamic syndrome of mature age (n=158); Group IV ‒ constitutional-exogenous obesity of mature age (n=78). Results. In groups of patients with hypothalamic syndrome, a higher level of morning cortisol (р<0.05), evening cortisol (р<0.05), prolactin (р<0.05), luteinizing hormone (р<0.05), follicle-stimulating hormone (р<0.05) than in patients with constitutionally-exogenous obesity. In groups of patients with hypothalamic syndrome, lower testosterone levels were recorded than in patients with constitutionally-exogenous obesity (р<0.05). Violation of the daily rhythm of cortisol production was more common in patients with hypothalamic syndrome than in constitutionally-exogenous obesity (р<0.05). In groups of patients with hypothalamic syndrome, the incidence of high prolactin was higher than in groups of patients with constitutionally-exogenous obesity (p<0.05). In groups of patients with signs of hypothalamic syndrome, low testosterone levels were more common than with constitutionally exogenous obesity (p<0.05). Conclusion. The data obtained indicate a higher functional activity of the hypothalamus-pituitary-adrenal axis and lower functional activity of the hypothalamus-pituitary-gonads axis in patients with hypothalamic syndrome in comparison with patients with constitutionally-exogenous obesity.

Key words: hypothalamus dysfunction, hypothalamic obesity, obesity in adolescents, hormonal disorders in adolescents, hormonal disorders in young men


 
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How to Cite this Article
Pubmed Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko. HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY. JCR. 2020; 7(4): 42-49. doi:10.31838/jcr.07.04.10


Web Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko. HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY. http://www.jcreview.com/?mno=92942 [Access: May 30, 2021]. doi:10.31838/jcr.07.04.10


AMA (American Medical Association) Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko. HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY. JCR. 2020; 7(4): 42-49. doi:10.31838/jcr.07.04.10



Vancouver/ICMJE Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko. HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY. JCR. (2020), [cited May 30, 2021]; 7(4): 42-49. doi:10.31838/jcr.07.04.10



Harvard Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko (2020) HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY. JCR, 7 (4), 42-49. doi:10.31838/jcr.07.04.10



Turabian Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko. 2020. HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY. Journal of Critical Reviews, 7 (4), 42-49. doi:10.31838/jcr.07.04.10



Chicago Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko. "HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY." Journal of Critical Reviews 7 (2020), 42-49. doi:10.31838/jcr.07.04.10



MLA (The Modern Language Association) Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko. "HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY." Journal of Critical Reviews 7.4 (2020), 42-49. Print. doi:10.31838/jcr.07.04.10



APA (American Psychological Association) Style

L.K. Tsertsvadze, M.V. Avdeeva, L.V. Scheglova, Vasiliy Ivanovich Orel,V.S. Vasilenko (2020) HORMONAL CHANGES IN THE HYPOTHALAMUS-PITUITARY-ADRENAL- GONADS SYSTEM IN YOUNG MEN WITH HYPOTHALAMIC OBESITY. Journal of Critical Reviews, 7 (4), 42-49. doi:10.31838/jcr.07.04.10