ISSN 2394-5125
 

Review Article 


MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM.

Abstract
Constipation disproportionately affects older adults, with a prevalence of 50% in community-dwelling elderly and 74% in nursing-home residents.
Loss of mobility, medications, underlying diseases, impaired anorectic sensation, and ignoring calls to defecate are as important as dyssynergic
defecation or irritable bowel syndrome in causing constipation. Opioid antagonists not only have well-established indications in the reversal of lifethreatening
opioid toxicity but also hold considerable promise for other applications in palliative care practice, particularly management of opioidinduced
constipation (OIC). This review summarizes the pharmacology of new peripherally acting mu (μ) opioid receptor antagonists (PAMORA).

Key words: Constipation, Opioid-Induced Constipation (OIC), Opioid receptor antagonists, Methylnaltrexone, Alvimopan, Naloxegol


 
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How to Cite this Article
Pubmed Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM. MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION. JCR. 2017; 4(5): 1-6. doi:10.22159/jcr.2017v4i5.22260


Web Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM. MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION. http://www.jcreview.com/?mno=302644756 [Access: April 18, 2021]. doi:10.22159/jcr.2017v4i5.22260


AMA (American Medical Association) Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM. MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION. JCR. 2017; 4(5): 1-6. doi:10.22159/jcr.2017v4i5.22260



Vancouver/ICMJE Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM. MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION. JCR. (2017), [cited April 18, 2021]; 4(5): 1-6. doi:10.22159/jcr.2017v4i5.22260



Harvard Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM (2017) MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION. JCR, 4 (5), 1-6. doi:10.22159/jcr.2017v4i5.22260



Turabian Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM. 2017. MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION. Journal of Critical Reviews, 4 (5), 1-6. doi:10.22159/jcr.2017v4i5.22260



Chicago Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM. "MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION." Journal of Critical Reviews 4 (2017), 1-6. doi:10.22159/jcr.2017v4i5.22260



MLA (The Modern Language Association) Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM. "MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION." Journal of Critical Reviews 4.5 (2017), 1-6. Print. doi:10.22159/jcr.2017v4i5.22260



APA (American Psychological Association) Style

OZAIFA KAREEM, NASIR NISAR, NAHIDA TABASSUM (2017) MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION. Journal of Critical Reviews, 4 (5), 1-6. doi:10.22159/jcr.2017v4i5.22260