ISSN 2394-5125
 

Review Article 


IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES

RIZALDY TASLIM PINZON, ROSA DE LIMA RENITA SANYASI.

Abstract
Two main strategies have been suggested for the treatment of ischemic stroke including reperfusion and neuroprotection. Citicoline is one of
neuroprotector agent that commonly used in ischemic stroke. A systematic review of citicoline focusing only on ischemic stroke has not yet
performed. This systematic review aimed to identify the effectiveness of citicoline in patients with ischemic stroke history. A systematic research
was performed using PubMed and Cochrane Library as the database. Keywords were: “citicoline and stroke”, “citicoline and ischemic stroke”, and
“randomized controlled trial citicoline". The inclusion criteria were: (i) the trials conducted between 2007 to 2017, (ii) written in English, (iii) the
studies performed in human, (iv) patients had ischemic stroke history, (v) citicoline was the main drug assessed in the study. The exclusion criteria
i.e.: (i) the study was not a randomized controlled trial (RCT) and (ii) the full text was not available. The quality of RCT was determined by using
Jadad score. A literature search revealed 541 journals from PubMed and Cochrane Library. After screening the title and abstract, adjusting for
inclusion and exclusion criteria, adjusting for the irrelevant topic, and duplication the final result was 4 RCT studies. All studies had a good quality,
indicated by Jadad score of 3 or more. Three studies conclude that no statistically significant difference in treatment outcome between citicoline and
other groups. The last study revealed citicoline is effective in preventing post-stroke cognitive impairment.

Key words: Systematic review, Citicoline, Ischemic stroke


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by RIZALDY TASLIM PINZON
Articles by ROSA DE LIMA RENITA SANYASI
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

PINZON RT, SANYASI RDLR. IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES. JCR. 2018; 5(3): 11-14. doi:10.22159/jcr.2018v5i3.24568


Web Style

PINZON RT, SANYASI RDLR. IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES. http://www.jcreview.com/?mno=302644743 [Access: May 31, 2021]. doi:10.22159/jcr.2018v5i3.24568


AMA (American Medical Association) Style

PINZON RT, SANYASI RDLR. IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES. JCR. 2018; 5(3): 11-14. doi:10.22159/jcr.2018v5i3.24568



Vancouver/ICMJE Style

PINZON RT, SANYASI RDLR. IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES. JCR. (2018), [cited May 31, 2021]; 5(3): 11-14. doi:10.22159/jcr.2018v5i3.24568



Harvard Style

PINZON, R. T. & SANYASI, . R. D. L. R. (2018) IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES. JCR, 5 (3), 11-14. doi:10.22159/jcr.2018v5i3.24568



Turabian Style

PINZON, RIZALDY TASLIM, and ROSA DE LIMA RENITA SANYASI. 2018. IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES. Journal of Critical Reviews, 5 (3), 11-14. doi:10.22159/jcr.2018v5i3.24568



Chicago Style

PINZON, RIZALDY TASLIM, and ROSA DE LIMA RENITA SANYASI. "IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES." Journal of Critical Reviews 5 (2018), 11-14. doi:10.22159/jcr.2018v5i3.24568



MLA (The Modern Language Association) Style

PINZON, RIZALDY TASLIM, and ROSA DE LIMA RENITA SANYASI. "IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES." Journal of Critical Reviews 5.3 (2018), 11-14. Print. doi:10.22159/jcr.2018v5i3.24568



APA (American Psychological Association) Style

PINZON, R. T. & SANYASI, . R. D. L. R. (2018) IS THERE ANY BENEFIT OF CITICOLINE FOR ACUTE ISCHEMIC STROKE ? SYSTEMATIC REVIEW OF CURRENT EVIDENCES. Journal of Critical Reviews, 5 (3), 11-14. doi:10.22159/jcr.2018v5i3.24568