ISSN 2394-5125
 

Review Article 


DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES

P. V. S. S SANJAYMITRA, G. N. K. GANESH.

Abstract
The solubility is one of the important parameters to achieve the desired concentration of the drug in the systemic circulation in pharmacological
response to be shown. The oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effects, but
the poor solubility of the drug is a major challenge for formulation scientist. Close to 40% of orally administered drugs suffer from formulation
difficulties related to their water insolubility. Dissolution rate, absorption, distribution, and excretion of a moiety depend upon its solubility
characteristics. Although several advantages associated with the oral route, the poorly soluble drugs suffer from slow dissolution and poor
bioavailability. Based on solubility, drugs are classified into four classes of the BCS classification. Solubility challenges are faced in ClassII and Class
IV of the BCS system this is important because most of the generic and NCE drugs come under class II drugs. The solubility behavior of drugs
remains one of the most challenging aspects of formulation development. There are several methods available for solubility and dissolution
enhancement of poorly water-soluble drugs. The aim of this clause is to distinguish the techniques of solubilization for the acquisition of effective
absorption and improved bioavailability.

Key words: Solubility, Biopharmaceutical classification (BCS), pH, Dissolution


 
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Pubmed Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH. DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES. JCR. 2018; 5(3): 1-10. doi:10.22159/jcr.2018v5i3.23451


Web Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH. DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES. http://www.jcreview.com/?mno=302644742 [Access: June 01, 2021]. doi:10.22159/jcr.2018v5i3.23451


AMA (American Medical Association) Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH. DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES. JCR. 2018; 5(3): 1-10. doi:10.22159/jcr.2018v5i3.23451



Vancouver/ICMJE Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH. DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES. JCR. (2018), [cited June 01, 2021]; 5(3): 1-10. doi:10.22159/jcr.2018v5i3.23451



Harvard Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH (2018) DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES. JCR, 5 (3), 1-10. doi:10.22159/jcr.2018v5i3.23451



Turabian Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH. 2018. DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES. Journal of Critical Reviews, 5 (3), 1-10. doi:10.22159/jcr.2018v5i3.23451



Chicago Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH. "DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES." Journal of Critical Reviews 5 (2018), 1-10. doi:10.22159/jcr.2018v5i3.23451



MLA (The Modern Language Association) Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH. "DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES." Journal of Critical Reviews 5.3 (2018), 1-10. Print. doi:10.22159/jcr.2018v5i3.23451



APA (American Psychological Association) Style

P. V. S. S SANJAYMITRA, G. N. K. GANESH (2018) DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES. Journal of Critical Reviews, 5 (3), 1-10. doi:10.22159/jcr.2018v5i3.23451