ISSN 2394-5125
 

Research Article 


SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN.

Abstract
We prepared and characterized trinuclear Schiff base transition metal compounds. Compounds were
synthesised from p-phenylenediamine, benzil and 3-aminocoumarin and Cu (II), Ni (II), Mn (II), Zn (II) and Cr
(III) salts. The type of the compounds was [M3LCl6]. The characterization and details of bonding of prepared
trinuclear Schiff base compounds have been confirmed by physico chemical method and spectral studies such as
infrared, ultraviolet-visible, cyclic voltametry, EPR, magnetic property and Thermogravimetric methods. Gel
electrophoresis method was used to understand pUC18 DNA cleavage study. The results established that Schiff
base complexes cleaved DNA in presence of H2O2. Additionally, the antibacterial activity was experienced by disc
diffusion method. The antibacterial action of compounds was tested against bacteria such as Klebsiella
pneumoniae, Escherichia coli, and Staphylococcus aureus.

Key words: P-phenylenediamine, benzil, 3-amino coumarin, Ultraviolet-visible spectra, cyclic voltametry and DNA cleavage study


 
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Pubmed Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN. SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND. JCR. 2020; 7(4): 2769-2778. doi:10.31838/jcr.07.04.420


Web Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN. SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND. http://www.jcreview.com/?mno=136016 [Access: May 30, 2021]. doi:10.31838/jcr.07.04.420


AMA (American Medical Association) Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN. SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND. JCR. 2020; 7(4): 2769-2778. doi:10.31838/jcr.07.04.420



Vancouver/ICMJE Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN. SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND. JCR. (2020), [cited May 30, 2021]; 7(4): 2769-2778. doi:10.31838/jcr.07.04.420



Harvard Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN (2020) SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND. JCR, 7 (4), 2769-2778. doi:10.31838/jcr.07.04.420



Turabian Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN. 2020. SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND. Journal of Critical Reviews, 7 (4), 2769-2778. doi:10.31838/jcr.07.04.420



Chicago Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN. "SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND." Journal of Critical Reviews 7 (2020), 2769-2778. doi:10.31838/jcr.07.04.420



MLA (The Modern Language Association) Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN. "SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND." Journal of Critical Reviews 7.4 (2020), 2769-2778. Print. doi:10.31838/jcr.07.04.420



APA (American Psychological Association) Style

KUTTIYAPILLAI SIVAKUMAR, VENKATACHALAM CHANDRASEKARAN (2020) SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE AND BIOLOGICAL ACTIVITIES OF SCHIFF BASE DERIVED FROM P-PHENYLENEDIAMINE, BENZIL AND 3-AMINOCOUMARIN AND THEIR TRANSITION METAL COMPOUND. Journal of Critical Reviews, 7 (4), 2769-2778. doi:10.31838/jcr.07.04.420