ISSN 2394-5125
 

Research Article 


ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth.

Abstract
The goal of this research is to explore the antiurolithiatic ability of bioactive compounds of Berberis asiatica loaded Chitosan
nanoparticles (BACBANPs) toward ethylene glycol engendered renal calculi in albino Wister rat species. Calcium oxalate
renal calculi were activated by ingestion of 0.75% (v/v) ethylene glycol and 1% (w/v) ammonium chloride in male Wister
rats. Reference standard Cystone; bioactive compounds of B. asiatica (BACBA) and BACBANPs were provided at oral dose
of 750 mg/kg, 400 mg/kg and 400 mg equivalent weight of BACBANPs/kg, respectively. The curative and prophylactic
consequences of BACBANPs were estimated. Urinary variables include calcium, magnesium, uric acid, phosphate and
oxalate; intensification of oxalate and calcium in the kidney; and serum uric acid, creatinine, calcium, and blood urea
nitrogen were evaluated. Creatinine clearance has been computed. Specifications of In vivo antioxidant investigations include
reduced glutathione, superoxide dismutase, lipid peroxidation, and catalase; and histopathological studies of the kidney were
analyzed. After treated with cystone, BACBA, and BACBANPs, the serum, urine parameters, and in vivo antioxidant
specifications were almost normalized in prophylactic and curative regimens compared to control groups. Loading of
BACBA in Chitosan nanoparticles in which Chitosan serves as a ligand to megalin receptors on renal epithelial cells
contributes to targeting and promotes the accumulation of BACBA than administered alone. It was concluded that the
antiurolithiatic activity of BACBANPs was substantially escalated in comparison to BACBA and cystone.

Key words: Urolithiasis, Bio active compounds of Berberis asiatica (BACBA), Chitosan nanoparticles.


 
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How to Cite this Article
Pubmed Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth. ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS . JCR. 2020; 7(5): 2400-2409. doi:10.31838/jcr.07.05.406


Web Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth. ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS . http://www.jcreview.com/?mno=134206 [Access: August 17, 2021]. doi:10.31838/jcr.07.05.406


AMA (American Medical Association) Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth. ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS . JCR. 2020; 7(5): 2400-2409. doi:10.31838/jcr.07.05.406



Vancouver/ICMJE Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth. ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS . JCR. (2020), [cited August 17, 2021]; 7(5): 2400-2409. doi:10.31838/jcr.07.05.406



Harvard Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth (2020) ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS . JCR, 7 (5), 2400-2409. doi:10.31838/jcr.07.05.406



Turabian Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth. 2020. ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS . Journal of Critical Reviews, 7 (5), 2400-2409. doi:10.31838/jcr.07.05.406



Chicago Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth. "ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS ." Journal of Critical Reviews 7 (2020), 2400-2409. doi:10.31838/jcr.07.05.406



MLA (The Modern Language Association) Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth. "ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS ." Journal of Critical Reviews 7.5 (2020), 2400-2409. Print. doi:10.31838/jcr.07.05.406



APA (American Psychological Association) Style

Kishore Bandarapalle, Prasanna Raju Yalavarthi, Chandra Sekhar Kothapalli Bannoth (2020) ANTIUROLITHIATIC ACTIVITY OF BIOACTIVE COMPOUNDS OF BERBERIS ASIATICA LOADED CHITOSAN NANOPARTICLES TOWARD ETHYLENE GLYCOL ACTIVATED UROLITHIASIS IN ALBINO WISTER RATS . Journal of Critical Reviews, 7 (5), 2400-2409. doi:10.31838/jcr.07.05.406