ISSN 2394-5125
 

Research Article 


PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari.

Abstract
Commonly used preparation involves the reinfusion of ex-vivo derived DC pulsed with tumorassociated
antigens (TAAs) or tumor cell lysates and stimulated with a defined maturation cocktail. within the
earlier trials, the gold standard maturation cocktail included the pro-inflammatory cytokines TNF-α, IL-1β, and
IL-6 together with prostaglandin E2 (PGE2). One approach commonly used to circumvent the DC dysfunction
in cancer is the ex-vivo conditioning of DC for immunotherapy. In the last 10 years, numerous clinical trials
have been started aiming to improve the performance of the immune system for the eradication of tumours.
While the overall results are not overwhelmingly positive, there are good indications that this approach may
work. However, despite the important roles of PGE2 in promoting DC migration and in enhancing T cell
proliferation, it's also been shown that PGE2 may induce differentiation of regulatory T cells increase the
expression of the pro-tolerogenic enzyme, indoleamine 2,3-dioxygenase (IDO) and will limit IL12p70
production.

Key words: Immunotherapy, Pro-Tolerogenic Enzyme, Indoleamine 2,3-Dioxygenase, Pattern Recognition Receptors, Pro- Inflammatory Cytokines, Immunomodulatory Molecules.


 
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How to Cite this Article
Pubmed Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari. PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW. JCR. 2020; 7(10): 2804-2811. doi:10.31838/jcr.07.10.460


Web Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari. PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW. http://www.jcreview.com/?mno=128591 [Access: August 17, 2021]. doi:10.31838/jcr.07.10.460


AMA (American Medical Association) Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari. PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW. JCR. 2020; 7(10): 2804-2811. doi:10.31838/jcr.07.10.460



Vancouver/ICMJE Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari. PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW. JCR. (2020), [cited August 17, 2021]; 7(10): 2804-2811. doi:10.31838/jcr.07.10.460



Harvard Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari (2020) PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW. JCR, 7 (10), 2804-2811. doi:10.31838/jcr.07.10.460



Turabian Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari. 2020. PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW. Journal of Critical Reviews, 7 (10), 2804-2811. doi:10.31838/jcr.07.10.460



Chicago Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari. "PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW." Journal of Critical Reviews 7 (2020), 2804-2811. doi:10.31838/jcr.07.10.460



MLA (The Modern Language Association) Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari. "PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW." Journal of Critical Reviews 7.10 (2020), 2804-2811. Print. doi:10.31838/jcr.07.10.460



APA (American Psychological Association) Style

Dr Venkata Kanthi Vaishnavi Vedam,Dr Sivadas Ganapathy,Dr Rajeev Arunachalam,Dr Koustabh Kumar,Dr. Sunil Kumar Gulia,Dr. Sasikanth Challari (2020) PERSONALIZED DENDRITIC CELL THERAPY IN THE TREATMENT OF CANCER- A REVIEW. Journal of Critical Reviews, 7 (10), 2804-2811. doi:10.31838/jcr.07.10.460