ISSN 2394-5125
 

Research Article 


SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS

Archana Pandita.

Abstract
Colorectal carcinogenesis (CRC) or colon cancer is a multi-step process which involves the accumulation in the colonic epithelial cells of molecular and genetic defects step-by-step, which means changes in the normal epithelium resulting from the hyper proliferation and ultimately from detectable carcinoma. Colon cancer is a type of cancer which is the second most common problem among women as compared to the third most common in among men worldwide. This cancer comes from one or collecion of the chromosomal instability, phenotype of the CpG island methylator & the instability of the microsatellite. It results in a major health pronblem in the developing countries. It comes from the collection of multiple genetic & epigenetic characteristics within the cells. It is a very common malignancy which is associated with the significant mortality rate. It is a slow and stepwise process of causing cancer to a person, in which the accumulations of mutations take place under the effect of genetic and environmental factors, the so called adenoma-carcinoma sequence. The genetic instability is generally caused by the aneuploidy & loss of heterozygosity. The presence of mutations in tumor suppressor or even cell cycle genes leads to the cellular transformation. The effective diagnosis and treatment knowledge based on the molecular characteristics of colorectal carcinogenesis are very important for the successful treatment of the colorectal carcinogenesis.

Key words: Aneuploidy, Colorectal Carcinogenesis (CRC), Chromosomal Instability, Cpg Island Methylator, Heterozygosity, Mutations.


 
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Pubmed Style

Archana Pandita. SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS. JCR. 2020; 7(3): 849-854. doi:10.31838/jcr.07.03.148


Web Style

Archana Pandita. SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS. http://www.jcreview.com/?mno=121141 [Access: April 17, 2021]. doi:10.31838/jcr.07.03.148


AMA (American Medical Association) Style

Archana Pandita. SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS. JCR. 2020; 7(3): 849-854. doi:10.31838/jcr.07.03.148



Vancouver/ICMJE Style

Archana Pandita. SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS. JCR. (2020), [cited April 17, 2021]; 7(3): 849-854. doi:10.31838/jcr.07.03.148



Harvard Style

Archana Pandita (2020) SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS. JCR, 7 (3), 849-854. doi:10.31838/jcr.07.03.148



Turabian Style

Archana Pandita. 2020. SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS. Journal of Critical Reviews, 7 (3), 849-854. doi:10.31838/jcr.07.03.148



Chicago Style

Archana Pandita. "SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS." Journal of Critical Reviews 7 (2020), 849-854. doi:10.31838/jcr.07.03.148



MLA (The Modern Language Association) Style

Archana Pandita. "SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS." Journal of Critical Reviews 7.3 (2020), 849-854. Print. doi:10.31838/jcr.07.03.148



APA (American Psychological Association) Style

Archana Pandita (2020) SIGNIFICANCE OF MOLECULAR CHARACTERISTICS OF COLORECTAL CARCINOGENESIS. Journal of Critical Reviews, 7 (3), 849-854. doi:10.31838/jcr.07.03.148