ISSN 2394-5125
 

Research Article 


Phospholipase PatA of Legionella pnemophila

Archan Pandita, Amit Kumar Singh.

Abstract
Phospholipases are varied enzyme group formed by eukaryote congregations and 3 harmful microbes. In recent years, the main ideas were received mostly over modes of activity for microbial phospholipases is addressed, that serve as strong film detiorator, controlling and activating host signaling pathways, such as expression of chemokine or an inflammatory cascade. Legionella pneumophila intracellular pulmonary lysopholpathogens exhibit phospholipase A (PLA) and lysophospholipase A (LPLA) actions of approx. three groups of enzymes. Three separate PLA and LPLA events showing the amino acid GDSL are identified in the first group; PlaA, PlaC and PlaD. Secondary assembly comprise very solid PLA / LPLa, PlaB. Tertiary cluster consists of 11 members, the patatin-like proteins. A patatin-centered protein, exhibits LPLA and PLA activity and, when expressed in yeast, inhibits vesicular trafficking and may therefore be involved. Similarly, the primary two groups of phospholipases possess part in infectious virulence as Phospholipases have been shown to facilitate the survival of bacteria, the spreading and damage / modification of host cell conditions. Legionella pneumophila is a water-borne human pneumonia bacterium. Bacterial phospholipases are considered a major virulence factor in bacterial pneumonia to degrade alveolar surfactant phospholipids. Bacterial phospholipase reaction products may possibly influence seven other mass cell procedures, like cell respiration, lamellopodia development, eight cell transportation and film circulation.

Key words: Alveolar surfactant phospholipids, Bacterial phospholipase, Chemokine, Inflammatory cascade, Legionella pneumophila, Lysophospholipase, Lamellopodia formation, Membrane traffic, Phospholipases, Signaling pathways, Vesicular trafficking.


 
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How to Cite this Article
Pubmed Style

Archan Pandita, Amit Kumar Singh. Phospholipase PatA of Legionella pnemophila. JCR. 2020; 7(7): 1300-1305. doi:10.31838/jcr.07.07.236


Web Style

Archan Pandita, Amit Kumar Singh. Phospholipase PatA of Legionella pnemophila. http://www.jcreview.com/?mno=120814 [Access: May 31, 2021]. doi:10.31838/jcr.07.07.236


AMA (American Medical Association) Style

Archan Pandita, Amit Kumar Singh. Phospholipase PatA of Legionella pnemophila. JCR. 2020; 7(7): 1300-1305. doi:10.31838/jcr.07.07.236



Vancouver/ICMJE Style

Archan Pandita, Amit Kumar Singh. Phospholipase PatA of Legionella pnemophila. JCR. (2020), [cited May 31, 2021]; 7(7): 1300-1305. doi:10.31838/jcr.07.07.236



Harvard Style

Archan Pandita, Amit Kumar Singh (2020) Phospholipase PatA of Legionella pnemophila. JCR, 7 (7), 1300-1305. doi:10.31838/jcr.07.07.236



Turabian Style

Archan Pandita, Amit Kumar Singh. 2020. Phospholipase PatA of Legionella pnemophila. Journal of Critical Reviews, 7 (7), 1300-1305. doi:10.31838/jcr.07.07.236



Chicago Style

Archan Pandita, Amit Kumar Singh. "Phospholipase PatA of Legionella pnemophila." Journal of Critical Reviews 7 (2020), 1300-1305. doi:10.31838/jcr.07.07.236



MLA (The Modern Language Association) Style

Archan Pandita, Amit Kumar Singh. "Phospholipase PatA of Legionella pnemophila." Journal of Critical Reviews 7.7 (2020), 1300-1305. Print. doi:10.31838/jcr.07.07.236



APA (American Psychological Association) Style

Archan Pandita, Amit Kumar Singh (2020) Phospholipase PatA of Legionella pnemophila. Journal of Critical Reviews, 7 (7), 1300-1305. doi:10.31838/jcr.07.07.236