ISSN 2394-5125
 

Research Article 


EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri.

Abstract
Long time ago, phytotherapy constitutes a major health practice all over the world. Many medicinal plants such as Saussurea lappa (S. lappa) has wide beneficial roles. This study was contrived to explore the antiphlogistic effect of S. lappa roots extract treated by 100% ethanol solvent. Carrageenan induced paw edema model was used to carry out the experiment on laboratory Wistar albino rats. Before testing extract on animals, it was necessary to check the safety of the plant according to performed testing conditions albeit S. lappa is generally recognized as safe plant, hence the acute oral toxicity test by the fixed-dose procedure method (FDP) was performed. Roots’ ethanol extract tested at two doses (100 and 200 mg/kg), ibuprofen used as a positive control, and negative control was distilled water. SPSS statistical analysis was undertaken to check the variance between tested groups via one-way analysis of variance, then pursued by Tukey and Dunnett two-sided tests. FDP experiment disclosed that extract was safe for further in-vivo testing for the dose up to 2000 mg/kg < LD50 < 5000 mg/kg, without reporting of any toxicity signs. The extract manifested a significant (P < 0.05 - 0.01) anti-inflammatory effects at both tested doses. The ethanol extract exposed a clear decrease in edema size by a percentage of 13.73 % at 200 mg/kg dose when compared to that of standard agent which minimized edema by 22.79 %. It is presumed that plant roots contain phytoconstituents that are responsible to share this effect like sesquiterpene lactones (dehydrocostus lactone and cynaropicrin mainly), in which many researches revealed that such compounds which found in many other plants have a potent anti-inflammatory action.

Key words: Anti-inflammatory effect, Saussurea lappa, Ethanol extract, Soxhlet extraction.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Amad A. El Marghani
Articles by Mohammed Abdelfatah Alhoot
Articles by P.M. Ridzuan
Articles by Mahfoudh A. M. Abdulghani
Articles by Tee Yee Sim
Articles by Khaled Algariri
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri. EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT. JCR. 2020; 7(19): 9795-9802. doi:10.31838/jcr.07.19.1083


Web Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri. EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT. http://www.jcreview.com/?mno=11973 [Access: August 17, 2021]. doi:10.31838/jcr.07.19.1083


AMA (American Medical Association) Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri. EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT. JCR. 2020; 7(19): 9795-9802. doi:10.31838/jcr.07.19.1083



Vancouver/ICMJE Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri. EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT. JCR. (2020), [cited August 17, 2021]; 7(19): 9795-9802. doi:10.31838/jcr.07.19.1083



Harvard Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri (2020) EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT. JCR, 7 (19), 9795-9802. doi:10.31838/jcr.07.19.1083



Turabian Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri. 2020. EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT. Journal of Critical Reviews, 7 (19), 9795-9802. doi:10.31838/jcr.07.19.1083



Chicago Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri. "EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT." Journal of Critical Reviews 7 (2020), 9795-9802. doi:10.31838/jcr.07.19.1083



MLA (The Modern Language Association) Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri. "EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT." Journal of Critical Reviews 7.19 (2020), 9795-9802. Print. doi:10.31838/jcr.07.19.1083



APA (American Psychological Association) Style

Amad A. El Marghani, Mohammed Abdelfatah Alhoot, P.M. Ridzuan, Mahfoudh A. M. Abdulghani, Tee Yee Sim, Khaled Algariri (2020) EVALUATION OF ANTI-INFLAMMATORY INFLUENCES OF SAUSSUREA LAPPA ROOTS ETHANOL EXTRACT. Journal of Critical Reviews, 7 (19), 9795-9802. doi:10.31838/jcr.07.19.1083