ISSN 2394-5125
 

Research Article 


BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran.

Abstract
In addition to providing effective antiulcer medicines, their suboptimum safety and efficacy also stirs the search for alternative therapies. Repositioning of drugs is an attractive, convenient, and low risk strategy. The Phytoconstituents Bacoside A, Withanolide A and shatavarin IV obtained from the medicinal plants. The purpose of this analysis was to look at the mechanism of action underling the ulcer protective and ulcer healing capability of these phytoconstituents. The acute toxicity experiment was performed to look for the toxicity of the phytoconstituents, gastro protective effect determined using pylorus ligation induced ulcer model, connection of NO, SH and PGE2 were also tested. Peptic ulcer induced by acetic acid model, Western blotting assay (COX-1 and COX-2) was also performed to elucidate the mechanism of action of Phytoconstituents. No mortality was detected at given dosage in the acute toxicity study. In ulcer protective activity the phytoconstituents, Bacoside A and Shatavarin IV at the dose of 200g/ml/kg, Withanolide A at the dose of 20g/ml/kg appreciably reduced the ulcer index and ulcer severity in pylorus ligation induced ulcer model, the antiulcer ability involves several mechanisms like, non participation of NO and SH compounds. Improvement of PGE2 range and the up regulation of COX-2 seems to be directly related to the phytoconstituents antisecretory, ulcer-protective effects. These findings accentuate the gastro protective and gastric healing potency of the Phytoconstituents were mediated via concerted multi-pronged actions, including promotion of gastric protection, augmentation of PGE2, up regulation of COX-II.

Key words: Bacoside A; Phytoconstituents; PGE2; Shatavarin IV; Withanolide A.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by JignyashaAmitkumar Raval
Articles by R. Manivannan
Articles by S. Kameshwaran
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran. BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS. JCR. 2020; 7(9): 1094-1102. doi:10.31838/jcr.07.09.202


Web Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran. BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS. http://www.jcreview.com/?mno=115806 [Access: May 30, 2021]. doi:10.31838/jcr.07.09.202


AMA (American Medical Association) Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran. BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS. JCR. 2020; 7(9): 1094-1102. doi:10.31838/jcr.07.09.202



Vancouver/ICMJE Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran. BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS. JCR. (2020), [cited May 30, 2021]; 7(9): 1094-1102. doi:10.31838/jcr.07.09.202



Harvard Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran (2020) BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS. JCR, 7 (9), 1094-1102. doi:10.31838/jcr.07.09.202



Turabian Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran. 2020. BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS. Journal of Critical Reviews, 7 (9), 1094-1102. doi:10.31838/jcr.07.09.202



Chicago Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran. "BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS." Journal of Critical Reviews 7 (2020), 1094-1102. doi:10.31838/jcr.07.09.202



MLA (The Modern Language Association) Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran. "BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS." Journal of Critical Reviews 7.9 (2020), 1094-1102. Print. doi:10.31838/jcr.07.09.202



APA (American Psychological Association) Style

JignyashaAmitkumar Raval, R. Manivannan, S. Kameshwaran (2020) BACOSIDE A, WITHANOLIDE A, AND SHATAVARIN IV ARE BENEFICIAL ULCER AND ULCER HEALING ACTIVITY BY MODULATING INFLAMMATORY MEDIATORS IN RATS. Journal of Critical Reviews, 7 (9), 1094-1102. doi:10.31838/jcr.07.09.202