ISSN 2394-5125
 

Research Article 


THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso.

Abstract
The unpredictable chronic mild stress (UCMS) model has been widely accepted as an appropriate and valid model for
testing animal depression. Various studies have examined UCMS in rats for durations of 28 weeks with various types of
stressors. The aims of the study is to determine the duration of UCMS administration that causes depressive behavior in
rats. The methods used an experimental laboratory study with a true experimental design (randomized control group,
pre-test, and post-test design) was conducted with Rattus norvegicus at the Institute of Bio-Science of Universitas
Brawijaya. Five rats were given UCMS treatment for eight weeks. The depressive behavior of the rats was assessed
through a sucrose preference test (SPT), a tail suspension test (TST), and an open-field test (OFT) before treatment
(pre-test) and after four weeks (post-test I), six weeks (post-test II), and eight weeks (post-test III) of treatment. The data
analysis used a paired t-test and SPSS statistical tests with α = 0.05. This study found decreases in the sucrose consumption (the SPT test) four weeks (post-test I) and six weeks (post-test II) after the pre-test measurements. We also found
increases in the duration of immobility (the TPT test) six weeks (post-test II) after the pre-test measurements. In contrast,
no statistically significant changes were observed for the area units covered by the rats (the OFT test) in any of the
post-tests. UCMS administration causes depressive behavior in rats after six weeks.

Key words: UCMS, rats, depression, SPT, TST, OFT


 
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How to Cite this Article
Pubmed Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso. THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS . JCR. 2020; 7(4): 1644-1647. doi:10.31838/jcr.07.04.269


Web Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso. THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS . http://www.jcreview.com/?mno=110346 [Access: May 30, 2021]. doi:10.31838/jcr.07.04.269


AMA (American Medical Association) Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso. THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS . JCR. 2020; 7(4): 1644-1647. doi:10.31838/jcr.07.04.269



Vancouver/ICMJE Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso. THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS . JCR. (2020), [cited May 30, 2021]; 7(4): 1644-1647. doi:10.31838/jcr.07.04.269



Harvard Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso (2020) THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS . JCR, 7 (4), 1644-1647. doi:10.31838/jcr.07.04.269



Turabian Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso. 2020. THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS . Journal of Critical Reviews, 7 (4), 1644-1647. doi:10.31838/jcr.07.04.269



Chicago Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso. "THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS ." Journal of Critical Reviews 7 (2020), 1644-1647. doi:10.31838/jcr.07.04.269



MLA (The Modern Language Association) Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso. "THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS ." Journal of Critical Reviews 7.4 (2020), 1644-1647. Print. doi:10.31838/jcr.07.04.269



APA (American Psychological Association) Style

Sherly Limantara, Masruroh Rahayu, Noorhamdani, Ruslan Muhyi, Moch. Istiadjid Eddy Santoso (2020) THE DURATION OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) ADMINISTRATION FOR CAUSING DEPRESSIVE BEHAVIOR IN RATS . Journal of Critical Reviews, 7 (4), 1644-1647. doi:10.31838/jcr.07.04.269