ISSN 2394-5125
 

Research Article 


THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV.

Abstract
Background. Postoperative cognitive dysfunction (POCD) has been shown to be associated with long-term
disability, higher healthcare costs, and even increased mortality. Etiology of POCD is not clearly understood. The
induction of neuroinflammation, following the release of damage-associated patterns appears to play an important role.
Objective of study was to assess the influence of minor and major surgery on cognitive functions of rats.
Materials and Methods. Study was performed on rats (n=60). They were allocated to minor (n=20) and major
(n=20) surgery groups. For minor and major surgery group animals sham laparotomy and laparotomy with nephrectomy
was performed respectively under isoflurane anesthesia. Cognitive functions of rats were assessed from postoperative
day 7 to day 24 using Morris water maze (MWM) test and object recognition test. Results were compared to control
group (n=20).
Results. The learning session of MWM demonstrated learning ability in all group animals, but significant
learning deficit was observed in minor and major surgery groups. Short-term memory deficit was not observed in minor
surgery group, but in major surgery group it was observed in all parameters of MWM, time till 1st target area crossing
(tTAC, p=0.0004), target area crossings (TAC, p=0.01) and target quadrant time (TQT, p=0.02). Upon assessing longterm memory in minor surgery group TQT (p=0.004) and TAC (p=0.01) differed significantly in comparison to control
animals. In major group animals all test parameters were indicative of long-term memory impairment, tTAC (p=0.001),
TQT (p=0.0002) and TAC (p=0.008).
Object recognition 8 and 24 days after surgery did not reveal significant difference between minor surgery and
control group by discrimination index (p=0.21 and p=0.055), whereas major surgery group results indicated memory
deficit in both time periods (p=0.009 and p=0.002).
Conclusion. Both minor and major surgery may cause cognitive disorders in the postoperative period, but the
extent of cognitive function deficits were higher in major surgery group animals.

Key words: postoperative cognitive dysfunction, major surgery, Morris water maze, object recognition test.


 
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How to Cite this Article
Pubmed Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV. THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS . JCR. 2020; 7(5): 1833-1838. doi:10.31838/jcr.07.05.309


Web Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV. THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS . http://www.jcreview.com/?mno=110232 [Access: August 17, 2021]. doi:10.31838/jcr.07.05.309


AMA (American Medical Association) Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV. THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS . JCR. 2020; 7(5): 1833-1838. doi:10.31838/jcr.07.05.309



Vancouver/ICMJE Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV. THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS . JCR. (2020), [cited August 17, 2021]; 7(5): 1833-1838. doi:10.31838/jcr.07.05.309



Harvard Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV (2020) THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS . JCR, 7 (5), 1833-1838. doi:10.31838/jcr.07.05.309



Turabian Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV. 2020. THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS . Journal of Critical Reviews, 7 (5), 1833-1838. doi:10.31838/jcr.07.05.309



Chicago Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV. "THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS ." Journal of Critical Reviews 7 (2020), 1833-1838. doi:10.31838/jcr.07.05.309



MLA (The Modern Language Association) Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV. "THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS ." Journal of Critical Reviews 7.5 (2020), 1833-1838. Print. doi:10.31838/jcr.07.05.309



APA (American Psychological Association) Style

Visolatkhon Kh. SHARIPOVA, Abror A. VALIKHANOV, Azamat Kh. ALIMOV (2020) THE SURGICAL STRESS CAUSES POSTOPERATIVE COGNITIVE DYSFUNCTION IN RATS . Journal of Critical Reviews, 7 (5), 1833-1838. doi:10.31838/jcr.07.05.309