ISSN 2394-5125
 

Research Article 


COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES

Ragini Patil,, Dilip Gode, Pradeep Patil.

Abstract
The novel coronavirus SARS-Cov-2 infection which started as a cluster of viral pneumonia cases in Wuhan, China has rapidly spread globally though human-to-human transmission leading to a global pandemic. The causative coronavirus is structurally related to SARS coronavirus. The spike (S) protein on the virus binds to human ACE-2 receptor leading to viral entry into cell and infectivity. Most of the affected individual are either asymptomatic or experience a mild viral illness. However, a minority of patients have a complicated course with respiratory failure, ARDS and multiorgan failure leading to death, especially in those with advanced age or comorbidities. The diagnosis of COVIS-19 is by RT-PCR test on nasopharyngeal or oropharyngeal swab. Serologic tests are under development. Many antiviral medicines are currently under trial including hydroxychloroquine, remdesivir, lopinovir and ivermectin. The immune therapy options under trial include convalescent plasma, high dose intravenous immunoglobulins (IVIG) and anti-IL6 monoclonal antibody tocilizumab. Multiple trials are also underway to develop a vaccine to control this global pandemic. Various current potential targets include regions of the S protein.

Key words: SARS Cov 2, Clinical Syndrome, Pneumonia


 
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How to Cite this Article
Pubmed Style

Ragini Patil,, Dilip Gode, Pradeep Patil. COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES. JCR. 2020; 7(10): 104-107. doi:10.31838/jcr.07.10.26


Web Style

Ragini Patil,, Dilip Gode, Pradeep Patil. COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES. http://www.jcreview.com/?mno=110001 [Access: August 17, 2021]. doi:10.31838/jcr.07.10.26


AMA (American Medical Association) Style

Ragini Patil,, Dilip Gode, Pradeep Patil. COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES. JCR. 2020; 7(10): 104-107. doi:10.31838/jcr.07.10.26



Vancouver/ICMJE Style

Ragini Patil,, Dilip Gode, Pradeep Patil. COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES. JCR. (2020), [cited August 17, 2021]; 7(10): 104-107. doi:10.31838/jcr.07.10.26



Harvard Style

Ragini Patil,, Dilip Gode, Pradeep Patil (2020) COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES. JCR, 7 (10), 104-107. doi:10.31838/jcr.07.10.26



Turabian Style

Ragini Patil,, Dilip Gode, Pradeep Patil. 2020. COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES. Journal of Critical Reviews, 7 (10), 104-107. doi:10.31838/jcr.07.10.26



Chicago Style

Ragini Patil,, Dilip Gode, Pradeep Patil. "COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES." Journal of Critical Reviews 7 (2020), 104-107. doi:10.31838/jcr.07.10.26



MLA (The Modern Language Association) Style

Ragini Patil,, Dilip Gode, Pradeep Patil. "COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES." Journal of Critical Reviews 7.10 (2020), 104-107. Print. doi:10.31838/jcr.07.10.26



APA (American Psychological Association) Style

Ragini Patil,, Dilip Gode, Pradeep Patil (2020) COVID-19: CURRENT KNOWLEDGE OF CLINICAL SYNDROME AND TREATMENT ADVANCES. Journal of Critical Reviews, 7 (10), 104-107. doi:10.31838/jcr.07.10.26