ISSN 2394-5125
 

Research Article 


SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION

Denis V. Trubnikov, Alexander Yu. Gorobets, Elena V. Trubnikova, Alexander S. Belous.

Abstract
The rationale for the study is explained by the fact that regular application of probiotic feeding supplements in pig
breeding positively influences the growth and development of young stock, in particular, increases mean daily weight
gain, normalizes the performance of the gastrointestinal tract and enforces the resistance of the organism. For this reason,
a microencapsulated probiotic drug ―Enzymsporine withtrypsin‖ was developed in the facilities of Kursk State
Agricultural Academy (Kursk, Russia). The authors studied the drug’s biological safety. The main method of the study
of biological safety of the drug was the study of its subchronic toxicity that would allow for the production trials of this
drug on agricultural animals. The article presents the experimental data obtained during the tests on Wistar rats.The
tests on rats showed that new encapsulated probiotic drug ―Enzymsporine with trypsin‖ was safe in the doses that exceeded
the recommended for the application in animal farming by 2 and 10 times. This provided perspectives for the
application of this drug in animal production for the optimization of metabolism, an increase in the mass of animals, and
the safety of meat products for humans.

Key words: Enzymsporine, biological safety, microencapsulated probiotic preparation, trypsin, preclinical study, subchronic toxicity


 
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How to Cite this Article
Pubmed Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous. SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION. JCR. 2020; 7(9): 1922-1930. doi:10.31838/jcr.07.09.326


Web Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous. SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION. http://www.jcreview.com/?mno=104595 [Access: May 30, 2021]. doi:10.31838/jcr.07.09.326


AMA (American Medical Association) Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous. SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION. JCR. 2020; 7(9): 1922-1930. doi:10.31838/jcr.07.09.326



Vancouver/ICMJE Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous. SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION. JCR. (2020), [cited May 30, 2021]; 7(9): 1922-1930. doi:10.31838/jcr.07.09.326



Harvard Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous (2020) SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION. JCR, 7 (9), 1922-1930. doi:10.31838/jcr.07.09.326



Turabian Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous. 2020. SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION. Journal of Critical Reviews, 7 (9), 1922-1930. doi:10.31838/jcr.07.09.326



Chicago Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous. "SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION." Journal of Critical Reviews 7 (2020), 1922-1930. doi:10.31838/jcr.07.09.326



MLA (The Modern Language Association) Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous. "SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION." Journal of Critical Reviews 7.9 (2020), 1922-1930. Print. doi:10.31838/jcr.07.09.326



APA (American Psychological Association) Style

Denis V. Trubnikov , Alexander Yu. Gorobets , Elena V. Trubnikova, Alexander S. Belous (2020) SUBCHRONIC TOXICITY OF MICROENCAPSULATED PROBIOTIC DRUG “ENZYMSPORINE WITH TRYPSIN” AND ITS APPLICATION IN PIG PRODUCTION. Journal of Critical Reviews, 7 (9), 1922-1930. doi:10.31838/jcr.07.09.326