ISSN 2394-5125
 

Research Article 


PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES

Alexey V. Kovalev.

Abstract
A crucial direction in the development of biotechnology is production of human bioartificial organs and of related
products for tissue and organ engineering – constituent components for biofabrications of organs and tissues: human
biopolymers of extracellular matrix (ECM), cytokines, biomass of autologous and allogeneic human cells, organoids
and tissue spheroids, as well as special equipment – tissue bioreactors, bioprinters, etc. The biotechnology
development level today allows creating live ‗spare parts‘ for humans, and there is the prospect of competition with
manufacturers of prostheses and implants. The present review considers the unsolved problems of creating
bioartificial organs from the perspective of the classical triad of tissue engineering technology – cells, scaffold, and
bioreactor. The author focuses on clinical examples and discusses possible strategies and new approaches for
growing bioartificial organs inside in vivo bioreactors (hereinafter –regeneratrons) integrated with a living organism.
Regeneratrons are the latest generation of tissue bioreactorsrarely used in clinical practice yet with a potential of
increasing the efficiency of treatment.

Key words: Bioartificial organ, regenerative medicine, tissue engineering, regeneration, bioreactor, human trachea, transplantation, regeneratron, extracellular matrix; scaffolds.


 
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Pubmed Style

Alexey V. Kovalev. PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES. JCR. 2020; 7(9): 1813-1837. doi:10.31838/jcr.07.09.317


Web Style

Alexey V. Kovalev. PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES. http://www.jcreview.com/?mno=104566 [Access: April 17, 2021]. doi:10.31838/jcr.07.09.317


AMA (American Medical Association) Style

Alexey V. Kovalev. PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES. JCR. 2020; 7(9): 1813-1837. doi:10.31838/jcr.07.09.317



Vancouver/ICMJE Style

Alexey V. Kovalev. PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES. JCR. (2020), [cited April 17, 2021]; 7(9): 1813-1837. doi:10.31838/jcr.07.09.317



Harvard Style

Alexey V. Kovalev (2020) PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES. JCR, 7 (9), 1813-1837. doi:10.31838/jcr.07.09.317



Turabian Style

Alexey V. Kovalev. 2020. PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES. Journal of Critical Reviews, 7 (9), 1813-1837. doi:10.31838/jcr.07.09.317



Chicago Style

Alexey V. Kovalev. "PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES." Journal of Critical Reviews 7 (2020), 1813-1837. doi:10.31838/jcr.07.09.317



MLA (The Modern Language Association) Style

Alexey V. Kovalev. "PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES." Journal of Critical Reviews 7.9 (2020), 1813-1837. Print. doi:10.31838/jcr.07.09.317



APA (American Psychological Association) Style

Alexey V. Kovalev (2020) PROBLEMS OF CREATING BIOARTIFICIAL ORGANS AND THE COMPETITION OF MEDICAL TECHNOLOGIES. Journal of Critical Reviews, 7 (9), 1813-1837. doi:10.31838/jcr.07.09.317