ISSN 2394-5125
 
2021, Vol: 8, Issue: 8
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    SYNTHESIS AND ANTIBACTERIAL ACTIVI TY OF 1-(2-AMINO-4-FLURO-6-METHYL)-3-CHLORO-4-ARYL AZETITIN-2-ONES (2020)
    S. B. Waghmare
    JCR. 2020: 3181 - 3183

    Abstract

    4-Fluro-2-hydrazino-6-methyl 2 has been prepared by refluxing 2-amino-4-fluro-6-methyl benzothiazole 1 in ethanol with hydrazine hydrate. Compound 2 condensed independently with benzaldehyde, 2-hydroxy benzaldehyde, napthaldehyde and N, N-dimethylamino benzaldehyde to form corresponding hydrazones (3a- 3d) which were treated with chloroacetyl chloride to afford correpondig azetidin-2-ones (4a-4d). The structure of the compounds has been confirmed by elemental and spectral analysis. All the newly synthesised compounds were evaluated for their antibacterial activity.

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    Volume & Issue

    Volume 7 Issue-6

    Keywords

    Substituted benzothiazoles, Schiff bases, Azetidin-2-ones, Antibacterial activity.
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