Review on Synthesis of Isoniazid Based Hybrid Derivatives (2020)
Rashmi R. Mokal, Ratnnadeep C. Sawant and Deepa Y. Panhekar
JCR. 2020: 12804-12828
Abstract
Isoniazid is a first-line therapy for tuberculosis infection. Clinically, it has a track record as the most successful and extensively studied anti-tubercular drug in literature. It is an aromatic molecule having one nitrogen atom in a six-membered ring connected to an acid hydrazide moiety via a ketonic functional group. The presence of highly reactive sites in the molecule is largely responsible for its therapeutic action. The attractive molecular design of Isoniazid permits the preparation of numerous derivatives incorporating suitable moieties in drug design directed towards the development of more potent molecules for treating infectious diseases. We summarized the strategies for such synthesis of Isoniazid derivatives described in the literature over the last three years in this review.
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