Abstract

The present investigation deals with the study of in vitro anti-arthritic activity by inhibition of protein denaturation method by bovine serum albumin method and egg albumin method. Merremia dissecta Linn plant is a used in parts of leaf. It is used in the treatment of gout, Antipathogenic ,antimicrobial ,anti diuretics, alzheimer,and piles in Ayurvedic medicine, and traditionally used for the bone fracture. Method: The air-dried powder of M. dissecta Linn (leaves parts) was extracted using a Soxhlet apparatus with methanol as solvent. And preparation of silver nanoparticles .The extracts and its silver nanoparticles were concentrated under reduced pressure. The activities were carried out using the following concentration (100, 250 and 500 ?g/ml) and compared with diclofenac as standard drug. It has significant in vitro anti-arthritic in both the methods. Result: The Methanolic extract of M. dissecta possessed significant anti-arthritic property in ME of Merremia dissecta extract than compared to MEMD its silver nanoparticles. Conclusion: Activity may be due to the presence of the chemical profile such as phenolic acid, flavonoid (leuteotin), Germacrene and ?-sitosterol. The results of the study have suggested in the use of M.dissecta Linn and its silver nanoparticles as a potent anti-arthritic in several applications.

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