Abstract

SARS-Cov-2 refers to severe acute respiratory syndrome corona virus 2, which is the main reason of corona virus disease 2019 (COVID – 19), WHO recorded more than 347000 death due to the invasion of this virus. One of the most important symptoms appear with this infection is the high level of proinflammatory cytokines especially; IL-6. Beside that huge amounts of macrophage and T helper17 cell could be detected in the lung of the patients suggesting the name of cytokine storm. As other types of viral respiratory infection like Highly pathogenic avian influenza virus, the whole matter is about the competition between the human innate immune response and viral penetration to the lung via the cellular receptors which can recognize the pathogen. Here, there will be a abundant explanation or comparison with some similarities and dissimilarities between influenza A and COVID/19 viral infection which might explain detailed information about the invasion, attack and replication. In this paper, we tried to review some clinical and immunological similarities and dissimilarities which might appear upon the infection of human with influenza of COVID 19, depending on last findings which had been recorded in different research societies and clinical hospital during last few years hoping to give a clear explanation about the progress of disease and immunological response toward it .

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