Abstract

Adiposo genital syndrome is otherwise known as Froehlichs syndrome. It is manifested by a comb ination of symptoms along with obesity, delayed or absent puberty and disturbances in the production of hormones like growth hormone as well as anti diuretic hormone. Clinical manifestations of adiposo genital syndrome include obesity, incomplete sexual development, hypo gonadism poly dipsia as well as poly uria, behaviral as well as enotional changes, short stature, enhanced appetite and endocrine abnormalities. Diagnosis is dependent upon genital a bnormalities, medical history, hormonal assessment, imaging studies, bone age assessment and genetic testing. Sifferential diagnisis is based on hypothalamic disorders such as cranio pharyngioma, hypothalamic hamartoma, hypothalam ic injury and endocrine disorders such as primary hypothyroidism, cushings syndrome and poly cystic ovarian syndrime. Treatment is based on anti psychotic drugs, hormone replacement therapy, surgery, nutritional as well as life style management.

Description